How many employees work at Karyopharm Therapeutics?
Karyopharm Therapeutics, Inc. (KPTI) has approximately 226 total employees worldwide as of March 2026, according to Revelio Labs workforce intelligence data. Karyopharm Therapeutics’s total headcount has declined 35.1% from 348 employees in 2023 to 226 in 2026.
Is Karyopharm Therapeutics hiring right now?
Yes, Karyopharm Therapeutics is actively hiring. Karyopharm Therapeutics had 20 active job postings in 2026, a 35.3% increase from 2025 — see job openings & hiring trends.
About Karyopharm Therapeutics’s Workforce
Karyopharm Therapeutics, Inc. (KPTI) is a Pharmaceuticals company that employs 226 people worldwide as of March 2026. It is the 9th-largest by headcount among its peers. Founded in 2008, the company is headquartered in Newton, Massachusetts and trades on the NASDAQ.
Karyopharm Therapeutics's workforce has declined 35.1% from 2023 to 2026, down 7.6% year over year in 2026. It fell to a low of 226 in 2026 Q1 before recovering. Its workforce is concentrated most in North America (96.1%), followed by Southeast Asia (1.4%) and Sub-Saharan Africa (0.7%).
Karyopharm Therapeutics's functional groups are Finance and Operations (45.7%), Sales and Marketing (36.4%), and Engineering (17.9%). The average salary is $218,464, ranging from a median of $203,000 in North America to $20,000 in Southeast Asia, up 2.4% year over year in 2026.
Karyopharm Therapeutics's active job postings rose 35.3% in 2026 to 20, with new postings per month cooling from 18 in 2023 to 11 in 2026. Overall employee sentiment is negative and declining.
Sourced from Revelio Labs workforce data.
- Ticker
- NASDAQ: KPTI
- Headquarters
- Newton, Massachusetts
- Founded
- 2008
- Industry
- Pharmaceuticals
- Employees
- 226
- YoY
- -7.6% (-37)
As of March 2026
Karyopharm Therapeutics workforce metrics
Unlock hiring rate, attrition rate, and 12 additional workforce metrics for Karyopharm Therapeutics. Compare to peers, export the dataset, and access the full quarterly history.
Unlock MetricsKaryopharm Therapeutics Annual Employee Count (2023-2026)
- Karyopharm Therapeutics had 226 employees in 2026, a 7.6% decline (-37) from 2025.
- Karyopharm Therapeutics had 229 employees in 2025, a 9.4% decline (-41) from 2024.
- Karyopharm Therapeutics had 270 employees in 2024, a 6.4% decline (-33) from 2023.
- Karyopharm Therapeutics had 303 employees in 2023, a 10.9% decline (-51) from 2022.
Karyopharm Therapeutics's total workforce has declined from 348 employees in 2023 to 226 in 2026.
Karyopharm Therapeutics, Inc. quarterly employee count
| Year | Qtr | Employees | YoY Change | YoY % |
|---|---|---|---|---|
| 2026 | Q1 | 226 | -37 | -7.6% |
| 2025 | Q4 | 229 | -41 | -9.4% |
| 2025 | Q3 | 228 | -50 | -11.0% |
| 2025 | Q2 | 258 | -43 | -8.0% |
| 2025 | Q1 | 263 | -34 | -6.8% |
| 2024 | Q4 | 270 | -33 | -6.4% |
| 2024 | Q3 | 278 | -34 | -7.3% |
| 2024 | Q2 | 301 | -47 | -8.9% |
| 2024 | Q1 | 297 | -52 | -9.8% |
| 2023 | Q4 | 303 | -51 | -10.9% |
| 2023 | Q3 | 312 | -60 | -9.9% |
| 2023 | Q2 | 348 | -58 | -6.5% |
See Karyopharm Therapeutics's complete headcount history, including quarterly breakdowns.
Get the DataKaryopharm Therapeutics Employee Count by Region (2026)
North America accounts for the largest share of Karyopharm Therapeutics's global workforce with approximately 96% of total employees, followed by Southeast Asia and Sub-Saharan Africa.
Karyopharm Therapeutics employees by region
| Region | Employees | % of Total |
|---|---|---|
| North America | 209 | 96.1% |
| Southeast Asia | 3 | 1.4% |
| Sub-Saharan Africa | 1 | 0.7% |
| Central and Western Asia | 1 | 0.5% |
| Pacific Islands | 1 | 0.4% |
| South Asia | 1 | 0.3% |
| Central America and the Caribbean | 1 | 0.3% |
| Western Europe | 1 | 0.2% |
Drill into city-level data, hiring trends by region, and historic geographic shifts.
Unlock Geographic DataKaryopharm Therapeutics Employee Count by Department (2026)
Karyopharm Therapeutics's employee groups are Finance and Operations (45.7%), Sales and Marketing (36.4%), and Engineering (17.9%).
Karyopharm Therapeutics employees by department
| Department | Employees | % of Total |
|---|---|---|
| Finance and Operations | 103 | 45.7% |
| Sales and Marketing | 82 | 36.4% |
| Engineering | 40 | 17.9% |
Compare Karyopharm Therapeutics's department mix to industry peers.
See Full DataKaryopharm Therapeutics Employee Salary by Region (2026)
Karyopharm Therapeutics's average employee salary is $218,464 globally. Employees in North America receive the highest compensation. Pay is lowest in Southeast Asia, at a median of $20,000.
Karyopharm Therapeutics median employee salary by region (USD)
| Region | Median Salary |
|---|---|
| North America | $203,000 |
| Southeast Asia | $20,000 |
Unlock salary by role, level, and city — and compare to Karyopharm Therapeutics's industry peers.
Unlock Salary DataKaryopharm Therapeutics Job Openings and Hiring Trends (2023-2026)
- Karyopharm Therapeutics had 20 active job postings in 2026, a 35.3% increase (+9) from 2025.
- Karyopharm Therapeutics had 11 active job postings in 2025, a 58.8% increase (+5) from 2024.
- Karyopharm Therapeutics had 6 active job postings in 2024, a 66.7% decline (-6) from 2023.
- Karyopharm Therapeutics had 12 active job postings in 2023, a 136.8% decline from 2022.
- Hiring velocity in 2026: 11 new roles/month, up from 7 in 2025 and 10 in 2024.
Karyopharm Therapeutics's active job postings rose 35.3% in 2026 to 20, with new postings per month cooling from 18 in 2023 to 11 in 2026.
Track new postings per month, role-level demand, and hiring velocity vs. peers.
Unlock Hiring DataKaryopharm Therapeutics Employee Sentiment (2026)
Revelio Labs tracks employee sentiment across Karyopharm Therapeutics's workforce based on public professional data. Overall sentiment is negative and has declined year over year in 2026.
Overall
Unlock the full sentiment breakdown by department, tenure, and trend over time.
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Frequently Asked Questions About Karyopharm Therapeutics
- How fast is Karyopharm Therapeutics growing?
- In 2026, Karyopharm Therapeutics's headcount shrank 7.6% to 226 employees, down from 263 in 2025.
- See the full headcount history
- Where are Karyopharm Therapeutics employees located?
- Most Karyopharm Therapeutics employees are based in North America (96.1% of headcount), followed by Southeast Asia and Sub-Saharan Africa.
- Explore where the workforce is based
- What is the average salary at Karyopharm Therapeutics?
- The average employee salary at Karyopharm Therapeutics is approximately $218.5k per year.
- Analyze the salary distribution
- How many new job postings does Karyopharm Therapeutics open per year?
- In Q1 2026, Karyopharm Therapeutics opened 34 new job postings. In 2025, Karyopharm Therapeutics opened 86 new job postings — about 7 per month.
- Track hiring trends by role
- When was Karyopharm Therapeutics founded and where is it headquartered?
- Karyopharm Therapeutics was founded in 2008 and is headquartered in Newton, Massachusetts.
- Compare Karyopharm Therapeutics to industry peers
Speak with a workforce expert about Karyopharm Therapeutics.
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