How many employees work at Sema4 OpCo?

Sema4 OpCo, Inc. has approximately 111 total employees worldwide as of March 2026, according to Revelio Labs workforce intelligence data. Sema4 OpCo’s total headcount has declined 38.3% from 180 employees in 2023 to 111 in 2026.

Data source: Revelio LabsCoverage: Global workforce, 2023–2026Published August 2026

Is Sema4 OpCo hiring right now?

Yes, Sema4 OpCo is actively hiring. Sema4 OpCo had 5 active job postings in 2026, a 85.7% increase from 2025 — see job openings & hiring trends.

About Sema4 OpCo’s Workforce

Sema4 OpCo, Inc. is a Healthcare and Wellness Services company that employs 111 people worldwide as of March 2026. It is the 10th-largest by headcount among its peers. Founded in 2015, the company is headquartered in Stamford, Connecticut.

Sema4 OpCo's workforce has declined 38.3% from 2023 to 2026, down 7.6% year over year in 2026. It fell to a low of 111 in 2026 Q1 before recovering. Its workforce is concentrated most in North America (98.7%), followed by South Asia (1.3%).

Sema4 OpCo's functional groups are Finance and Operations (45.3%), Engineering (31.4%), and Sales and Marketing (23.4%). The average salary is $141,644, highest in North America at a median of $129,000, down 2.7% year over year in 2026.

Sema4 OpCo's active job postings rose 85.7% in 2026 to 5. Overall employee sentiment is neutral but improving.

Sourced from Revelio Labs workforce data.

Headquarters
Stamford, Connecticut
Founded
2015
Industry
Healthcare and Wellness Services
Employees
111
YoY
-7.6% (-12)

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Sema4 OpCo Annual Employee Count (2023-2026)

Interactive chart of Sema4 OpCo annual worldwide employee count from 2023 to 2026.
  • Sema4 OpCo had 111 employees in 2026, a 7.6% decline (-12) from 2025.
  • Sema4 OpCo had 112 employees in 2025, a 8.4% decline (-14) from 2024.
  • Sema4 OpCo had 126 employees in 2024, a 10.7% decline (-19) from 2023.
  • Sema4 OpCo had 145 employees in 2023, a 51.4% decline (-304) from 2022.

Sema4 OpCo's total workforce has declined from 180 employees in 2023 to 111 in 2026.

Sema4 OpCo, Inc. quarterly employee count

YearQtrEmployeesYoY ChangeYoY %
2026Q1111-12-7.6%
2025Q4112-14-8.4%
2025Q3116-13-7.2%
2025Q2118-14-8.2%
2025Q1123-12-7.6%
2024Q4126-19-10.7%
2024Q3129-35-13.9%
2024Q2132-48-17.3%
2024Q1135-87-23.2%
2023Q4145-304-51.4%
2023Q3164-653-43.8%
2023Q2180-765-42.5%

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Sema4 OpCo Employee Count by Region (2026)

North America accounts for the largest share of Sema4 OpCo's global workforce with approximately 99% of total employees, followed by South Asia.

Sema4 OpCo employees by region

RegionEmployees% of Total
North America10898.7%
South Asia11.3%

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Sema4 OpCo Employee Count by Department (2026)

Sema4 OpCo's employee groups are Finance and Operations (45.3%), Engineering (31.4%), and Sales and Marketing (23.4%).

Sema4 OpCo employees by department

DepartmentEmployees% of Total
Finance and Operations5045.3%
Engineering3431.4%
Sales and Marketing2623.4%

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Sema4 OpCo Employee Salary by Region (2026)

Sema4 OpCo's average employee salary is $141,644 globally. Employees in North America receive the highest compensation.

Sema4 OpCo median employee salary by region (USD)

RegionMedian Salary
North America$129,000

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Sema4 OpCo Job Openings and Hiring Trends (2023-2026)

Interactive chart of Sema4 OpCo annual active job postings from 2023 to 2026.
  • Sema4 OpCo had 5 active job postings in 2026, a 85.7% increase (+4) from 2025.
  • Sema4 OpCo had 1 active job postings in 2025, a 0% no change from 2024.
  • Sema4 OpCo had 1 active job postings in 2024, a 175.0% decline (-14) from 2023.
  • Sema4 OpCo had 15 active job postings in 2023, a 200.0% increase from 2022.
  • Hiring velocity in 2026: 2 new roles/month, up from 0 in 2025 and 3 in 2024.

Sema4 OpCo's active job postings rose 85.7% in 2026 to 5.

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Sema4 OpCo Employee Sentiment (2026)

Revelio Labs tracks employee sentiment across Sema4 OpCo's workforce based on public professional data. Overall sentiment is neutral and has improved year over year in 2026.

Overall

NegativePositive

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Frequently Asked Questions About Sema4 OpCo

How fast is Sema4 OpCo growing?
In 2026, Sema4 OpCo's headcount shrank 7.6% to 111 employees, down from 123 in 2025.
See the full headcount history
Where are Sema4 OpCo employees located?
Most Sema4 OpCo employees are based in North America (98.7% of headcount), followed by South Asia.
Explore where the workforce is based
What is the average salary at Sema4 OpCo?
The average employee salary at Sema4 OpCo is approximately $141.6k per year.
Analyze the salary distribution
How many new job postings does Sema4 OpCo open per year?
In Q1 2026, Sema4 OpCo opened 5 new job postings. In 2025, Sema4 OpCo opened 4 new job postings — about 0 per month.
Track hiring trends by role
When was Sema4 OpCo founded and where is it headquartered?
Sema4 OpCo was founded in 2015 and is headquartered in Stamford, Connecticut.
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